Diagnosis and management of hereditary colorectal cancer syndromes: Lynch syndrome as a model.
نویسندگان
چکیده
منابع مشابه
Hereditary Nonpolyposis Colorectal Cancer (HNPCC)/Lynch Syndrome: Surveillance and Diagnostic strategies
Introduction: Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) is an autosomal dominant genetic disease. The disease is caused by a mutation in one of four genes of the DNA mismatch repair system and increases the risk for various cancers, especially the uterine and colon cancers. The prevalence of this disease in the general population is about 1 in 500 and it causes about 2-3...
متن کاملسندرم Lynch -l و گزارش شش مورد بیمار مبتلا
More than two decades ago, Henry T. Lynch reported a hereditary non polyposis colorectal cancer (HNPCC) which is seen in some families with dominant mode of inheritance, also know as Lynch Syndrome type I and II. This form to hereditary colorectal cancer has an early age of onset (Less than 45 years) with predominantly proximal colonic involvement (type I) and can also be associated with extrac...
متن کاملThe Lynch Syndrome: Melding Natural History and Molecular Genetics to Genetic Counseling and Cancer Control.
Hereditary nonpolyposis colorectal cancer (HNPCC), also referred to as Lynch syndromes I and II, is an autosomal, dominantly inherited disorder that accounts for approximately 5% of all colorectal cancers. While colorectal cancer is the most frequently occurring malignancy in HNPCC, other types of cancer occur with increased statistical significance. A better understanding of its natural histor...
متن کاملHNPCC (Lynch Syndrome): Differential Diagnosis, Molecular Genetics and Management - a Review
HNPCC (Lynch syndrome) is the most common form of hereditary colorectal cancer (CRC), wherein it accounts for between 2-7 percent of the total CRC burden. When considering the large number of extracolonic cancers integral to the syndrome, namely carcinoma of the endometrium, ovary, stomach, hepatobiliary system, pancreas, small bowel, brain tumors, and upper uroepithelial tract, these estimates...
متن کاملCommentary (Gruber et al)—What the Physician Needs to Know About Lynch Syndrome: An Update
In many respects, Lynch syndrome serves as the paradigm of cancer genetic syndromes. It is relatively common and accounts for approximately 3% to 5% of colorectal cancer cases. The genetic basis is clearly understood, and genetic testing is clinically available and routinely incorporated into clinical practice. Furthermore, the diagnosis has a profound impact on the management of individuals at...
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عنوان ژورنال:
- CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
دوره 181 5 شماره
صفحات -
تاریخ انتشار 2009